Carboxytherapy can improve peri-oral wrinkles by stimulating collagen synthesis. This area needs an local anesthesia with a cream (EMLA(tm)). Injections are make into the dermis (intradermal layers). There is one session per month in most of the cases. You should expect to have from 4 to 6 sessions for an optimal result

There is not down time. The first effects will take around 4 weeks to be seen (time for the collagen synthesis process to start).

Here is a braziian video which shows and gives information about rejuvenation of the peri-oral area using intradermal injections of carbon dioxide.